Showing posts with label Neuroscience. Show all posts
Showing posts with label Neuroscience. Show all posts

Sunday, June 13, 2021

How To Grow a Third Arm: Neuroplasticity, Synaptic Pruning, & Myelination



Learning By Doing


It's amazing —stunning, actually — how quickly the brain can adapt. A really wild example of the brain's adaptivity is growing a third arm. You can actually do this at home [1]. To grow a third arm, you will need the following supplies: 
  1. An accomplice 
  2. A rubber hand
  3. A small brush
  4. A blanket or towel
  5. A very sharp knife or hammer
First, place your real hand and the rubber hand next to each other. Then, cover up your arm with the blanket so only the hands are visible. Then, have your accomplice use the small brush to stroke both the real and fake hand at the same time. Do this for a minute. This step is crucial because you are creating a conflict in the brain that it must eventually resolve. In the final step, have your accomplice threaten the rubber hand with the knife or hammer. If the brain successfully completes the remapping, then you will withdraw your real hand because your mind has taken ownership of the fake hand [2]!

The Adaptive Brain

The "rubber hand illusion" isn't just a fun parlor trick to play with your friends at Halloween. Neuroscientists have figured out how get people to rewire their brains so they can control a third robotic arm [3].

These stunning demonstrations show how remarkably adaptable and resilient the brain is. This adaptivity is analogous to the mechanism the mind uses after suffering a trauma. For example, if a specific region of the brain is damaged, then it has some capability to accommodate that trauma. In extreme cases, the brain will adapt by overtaking adjacent tissue so the individual can regain some of their original functionality. 

What are the specific neural mechanisms for these adaptations, and what are some real-life implications?

Adaptivity and Late Bloomers

In a previous post, we learned that executive functioning (EF) is situated in the pre-frontal cortex (i.e., part of the brain just behind the forehead). Given its centrality to higher-order thinking, it is surprising to learn how late executive functioning develops. During young adulthood, the brain undergoes two important processes: synaptic pruning and myelination

Synaptic pruning sounds horrifying, but it is a necessary process whereby unnecessary synapses (i.e., the connections between neurons) are removed. 

Myelination is the process of adding a layer of lipids (or fat) to the outside neuron. The purpose of myelin is to speed up neural transmission. It's analogous to adding insulation to an electrical wire.

By most estimates, the frontal cortex isn't fully myelinated until a person reaches 25 years of age. That might explain why teenagers and young adults don't always make the best decisions. Their brain is still developing in the most critical region for planning, organization, response suppression, and (perhaps most importantly) counterfactual thinking! 

The Classroom Connection

Understanding the timeline for neural development also has an important implication for education. Some students are late bloomers and need extra time for their frontal lobe to fully develop [4]. To give these students the time they need, there should be some flexibility in their educational timeline. Taking a "gap year," traveling abroad, or enrolling in AmeriCorp might be precisely what these students need. Not all students should be expected to rush directly from high-school to college. 

In closing, we owe our brains a great debt of gratitude. Being adaptive and flexible is what makes us who we are. And who knows...maybe someday "being who we are," might include controlling a third arm. 💪


Share and Enjoy!

Dr. Bob

Going Beyond the Information Given

[1] The illusion of owning a third arm [link].

[2] Threatening a rubber hand that you feel is yours elicits a cortical anxiety response [link].

[3] Penaloza, C. I., & Nishio, S. (2018). BMI control of a third arm for multitaskingScience Robotics3(20).

[4] Karlgaard, R. (2019). Late BloomersThe Hidden Strengths of Learning and Succeeding at Your Own Pace. Broadway Business.


Wednesday, November 1, 2017

Reading Room Material: Stranger Things & The Frontal Lobe

If you're like me, then you are probably working your way through the second season of Stranger Things. Imagine my delight as this particular episode (s2e3) touched on a familiar topic.

Stranger Things: Season 2, Episode 3 "The Pollywog"

The main characters are listening to a lecture by their favorite teacher (complete with overhead transparencies!). He describes one of the most famous people in the history of neuroscience [1]:


Scott ClarkeThe case of Phineas Gage is one of the great medical curiosities of all time. Phineas was a railroad worker in 1848 who had a nightmarish accident. A large iron rod was driven completely through his head. Phineas miraculously survived. He seemed fine. And physically, yes, he was. But his injury resulted in a complete change to his personality.

The story of Phineas Gage is a well worn tale, and it is told in nearly every undergraduate neuroscience course. Thus, I found it extremely curious that Mr. Clarke was telling this story to his 5th grade science class. I also found it curious that Mr. Clarke ends the story with "a complete change to his personality." He didn't explain in what way Phineas changed. 

According to The American Phrenological Journal and Repository of Science (1851), Gage's physician reported that he had become, "gross, profane, course, and vulgar to such a degree that his society was intolerable to decent people" [2]. In other words, Gage became a jerk. Given the change in his personality, it was assumed that function of the frontal lobe was for inhibiting behaviors and thoughts. No frontal lobe? No inhibition. 

That doesn't sound like a very fulfilling life. However, if you continue to dig into this fascinating story, there is a small ray of hope (unfortunately, that ray doesn't always make it into the textbooks). A few years after he recovered from his injuries (including a fungal infection!), Phineas's personality renormalized. He wasn't such a jerk, and he even held down a job driving a stagecoach [3]. 

The story of Phineas Gage is hopeful because it demonstrates the brain's amazing ability to overcome severe trauma. He didn't live a very long life, but Gage remains immortalized in the annals of neuroscience (as well as the greatest TV series of all time). 


Share and Enjoy!

Dr. Bob


More Material

[1] Read the transcript or watch the full episode.

[2] Fowler, O. S., & Fowler, L.N. (Eds.). (1851). The American Phrenological Journal and Repository of Science, Literature and General Intelligence, Volumes 13-14, New York, NY: Fowlers & Wells, p. 89.

[3] Hamilton, J. (May 21, 2017Why Brain Scientists Are Still Obsessed With The Curious Case Of Phineas Gage Retrieved from npr.org.